ANIMAL
Charles River Laboratories, Inc.
CD-1® IGS Mouse
The original group of Swiss mice that served as progenitors of this stock consisted of two male and seven female albino mice derived from a non-inbred stock in the laboratory of Dr. de Coulon, Centre Anticancereux Romand, Lausanne, Switzerland. These animals were imported into the United States by Dr. Clara Lynch of the Rockefeller Institute in 1926. The Hauschka Ha/ICR stock was initiated in 1948 at the Institute for Cancer Research (ICR) in Philadelphia from “Swiss” mice of Rockefeller origin. To Dr. Edward Mirand of Roswell Park Memorial Institute where they were designated as HaM/ICR. To Charles River in 1959.
Coat Color: White (albino)
Ideal for: General multipurpose model, safety and efficacy testing, aging, pseudo pregnancy, surgical model.
CD® (Sprague Dawley) IGS Rat
Originated in 1925 by Robert W. Dawley from a hybrid hooded male and a female Wistar rat. To Charles River in 1950 from Sprague Dawley, Inc. In 1991, 8 colonies were selected to form the IGS Foundation Colony. Rederived into an isolator foundation colony in 1997. IGS refers to animals bred using the Charles River International Genetic Standardization Program.
Coat Color: White (albino)
Ideal for: General multipurpose model, safety and efficacy testing, aging, nutrition, diet-induced obesity, oncology, surgical model.
Wistar IGS Rat
To Scientific Products Farm, Ltd. [predecessor of Charles River United Kingdom (CRUK)] in 1947 from Wistar Institute. To Charles River in 1975 from CRUK. This particular colony was selected because of a low incidence of hydronephrosis. IGS refers to animals bred using the Charles River International Genetic Standardization (IGS) Program.
Coat Color: White (albino)
Ideal for: General multipurpose model, infectious disease research, safety and efficacy testing, aging, surgical model.
ZDF Rat
A mutation occurred in a colony of outbred Zucker rats in the laboratory of Dr. Walter Shaw at Eli Lilly Research Laboratories in Indianapolis, IN in 1974–75. Part of this colony containing the mutation was moved to Indiana University Medical School (IUMS), to the laboratory of Dr. Julia Clark in 1977. Several groups of animals with diabetic lineage were identified and rederived in 1981. Inbreeding of selected pairs from this rederivation was done in the laboratory of Dr. Richard Peterson at IUMS. A inbred line of ZDF rat was established in 1985. To Genetic Models, Inc. in 1991. To Charles River in 2001.
Coat Color: Black hooded with black stripe down the length of the back.
Ideal For: Type 2 diabetes*, hyperlipidemia, glucose intolerance, obesity, hyperinsulinemia.